Arnaud Iradukunda
Department of Global Health and Population,Takemi Program in International Health ,Harvard T.H. Chan School of Public Health, Boston,Massachusetts, USA; Faculty of Medicine, University of Burundi, Bujumbura, Burundi; Institute of Physical Education and Sports, University of Burundi, Bujumbura, Burundi; Department of Research and Innovation, ARNECH Research and Consulting Office, Bujumbura, Burundi; Royal Society of Tropical Medicine and hygiene, 303-306 High Holborn, London, UK; Faculté de Médicine, Maïeutique et Sciences de la Santé, Université de Strasbourg, Strasbourg, France; gIntegrated National Program for the Control of Neglected Tropical Diseases and Blindness, Ministry of Public Health and AIDS Control, Burundi;
Charles Gaturagi
Institute of Physical Education and Sports, University of Burundi, Bujumbura, Burundi;
Aimable Habonima
Faculty of Medicine, University of Burundi, Bujumbura, Burundi;
Martin Manirakiza
Faculty of Medicine, University of Burundi, Bujumbura, Burundi; Faculté de Médicine, Maïeutique et Sciences de la Santé, Université de Strasbourg, Strasbourg, France;
Victor Bucumi
Integrated National Program for the Control of Neglected Tropical Diseases and Blindness, Ministry of Public Health and AIDS Control, Burundi
Deogratias Nimpa
Integrated National Program for the Control of Neglected Tropical Diseases and Blindness, Ministry of Public Health and AIDS Control, Burundi
Emmanuel Nene Odjidja
Royal Society of Tropical Medicine and hygiene, 303-306 High Holborn, London, UK; Department of Monitoring and Evaluation, Global Community Engagement and Resilience Fund, Geneva, Switzerland;
Abstract
Background: Integrated national programme for the control of neglected tropical diseases and blindness aims to achieve a paradigm shift from control of morbidity to interruption of transmission and ultimately elimination.
Objective: The aim of this study was to understand onchocerciasis epidemiology and control strategies in the context of Burundi. Specifically, the study sought to understand the coverage of Ivermectin treatment in onchocerciasis endemic zones, to assess the impact of African Programme for Onchocerciasis Control (APOC) approach on treatment coverage and forecast the therapeutic coverage to 2030 horizon in Burundi.
Methods: We used retrospective data collected from 2005 to 2019 in four onchocerciasis endemic provinces in Burundi. For mapping and ivermectin coverage rates comparison, we respectively used a spatial analysis and welch testing methods. After, we forecasted the therapeutic coverage using the Autoregressive Integrated Moving Average (ARIMA) model, a statistical analysis model which uses time series data to predict future trends. All analysis were done using Quantum Geographic Information System (QGIS) and the R 3.5.3 software.
Results: During study period, a mean population of 1,536, 392 (95% CI: 1,114 ,870 -1,932 ,403) has been targeted by ivermectin treatment in all the four provinces. The ivermectin coverage rate was 77.8% (95% CI: 67.8% to 81.6%). Specifically, ivermectin coverage rates were 76.4%, 76.6% and 78.7% in Rutana, Bururi and Cibitoke – Bubanza respectively. After six years of massive drug administration under World Health Organization community guidelines launched in 2011, the coverage rates were, except the 2016 year, above 80%. Forecasts for 2030 showed that the coverage rate for treatment could increase.
Conclusion: This study showed that the ivermectin coverage rate significantly increased during the community-directed treatment approach period. The coverage rate should remain over 80% until 2030 in endemic regions, a strategy which should contribute to decrease the onchocerciasis prevalence and lead to onchocerciasis elimination.
